Heme domain plasticity Quaternary Structure Controls Ligand Dynamics in Soluble Guanylate Cyclase

نویسندگان

  • Byung-Kuk Yoo
  • Isabelle Lamarre
  • Jean-Louis Martin
  • Michel Negrerie
چکیده

Background: NO and CO dynamics are compared in soluble guanylate cyclase and isolated heme domain. Results: CO geminately rebinds to the isolated heme domain β1(190), contrary to entire sGC. Photo-oxidation of β1(190) heme may occur. Conclusion: The isolated heme domain β1(190) has a different reactivity than full-length sGC. Significance: The structural strains between domains in the full-length protein are crucial for its functioning.

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تاریخ انتشار 2012